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Metabolic changes in rats after intragastric administration of MGCD0103 (Mocetinostat), a HDAC class I inhibitor

MGCD0103, an isotype-selective HDACi, has been clinically evaluated for the treatment of hematologic malignancies and advanced solid tumors, alone and in combination with standard-of-care agents. In this study, we developed a serum metabolomic method based on gas chromatography-mass spectrometry (GC...

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Detalhes bibliográficos
Publicado no:Int J Clin Exp Pathol
Main Authors: Zhang, Qingwei, Wu, Haiya, Wen, Congcong, Sun, Fa, Yang, Xuezhi, Hu, Lufeng
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583915/
https://ncbi.nlm.nih.gov/pubmed/26464683
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