EVALUATION OF THE PHARMACODYNAMIC EFFECTS OF MGCD0103 FROM PRECLINICAL MODELS TO HUMAN, USING A NOVEL HDAC ENZYME ASSAY

PURPOSE: The pharmacodynamic properties of MGCD0103, an isotype-selective inhibitor of histone deacetylase (HDAC), were evaluated in preclinical models and patients with a novel whole cell HDAC enzyme assay. EXPERIMENTAL DESIGN: Boc-Lys(ε-Ac)-AMC, an HDAC substrate with fluorescent read-out, was fou...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bonfils, Claire, Kalita, Ann, Dubay, Marja, Siu, Lillian L., Carducci, Michael A., Reid, Gregory, Martell, Robert E., Besterman, Jeffrey M., Li, Zuomei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444140/
https://ncbi.nlm.nih.gov/pubmed/18519775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4427
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