The class-I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6-independent mechanism

Inhibition of histone deacetylase 6 (HDAC6)-dependent aggresome function by pan HDAC inhibitors was recently reported to be a key mechanism underlying the synergistic activity between proteasome inhibitors and HDAC inhibitors in a variety of tumour types. Because these combinations induce significan...

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Autori principali: Buglio, Daniela, Mamidipudi, Vidya, Khaskhely, Noor M., Brady, Helen, Heise, Carla, Besterman, Jeffrey, Martell, Robert E., MacBeth, Kyle, Younes, Anas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189488/
https://ncbi.nlm.nih.gov/pubmed/20880107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08342.x
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