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Investigations into the sequence-selective binding of mithramycin and related ligands to DNA.

The preferred binding sites for mithramycin on four different DNA fragments have been investigated by DNAase I footprinting. Sites containing at least two contiguous GC base pairs are protected by the antibiotic, the preferred binding site consisting of the dinucleotide step GpG (or CpC). Related an...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Fox, K R, Howarth, N R
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 1985
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC318945/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2934687/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/13.24.8695
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