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Investigations into the sequence-selective binding of mithramycin and related ligands to DNA.

The preferred binding sites for mithramycin on four different DNA fragments have been investigated by DNAase I footprinting. Sites containing at least two contiguous GC base pairs are protected by the antibiotic, the preferred binding site consisting of the dinucleotide step GpG (or CpC). Related an...

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Main Authors: Fox, K R, Howarth, N R
格式: Artigo
語言:Inglês
出版: 1985
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC318945/
https://ncbi.nlm.nih.gov/pubmed/2934687
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