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CD147 subunit of lactate/H(+) symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality. F...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3189052/ https://ncbi.nlm.nih.gov/pubmed/21930917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106123108 |
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