Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

BASIGIN/CD147/EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours. BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. However, before being reco...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Marchiq, Ibtissam, Albrengues, Jean, Granja, Sara, Gaggioli, Cédric, Pouysségur, Jacques, Simon, Marie-Pierre
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Priority Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694784/
https://ncbi.nlm.nih.gov/pubmed/26284589
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