CD147 subunit of lactate/H(+) symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality. F...

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Bibliographische Detailangaben
Hauptverfasser: Le Floch, Renaud, Chiche, Johanna, Marchiq, Ibtissam, Naiken, Tanesha, Ilc, Karine, Murray, Clare M., Critchlow, Susan E., Roux, Danièle, Simon, Marie-Pierre, Pouysségur, Jacques
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189052/
https://ncbi.nlm.nih.gov/pubmed/21930917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106123108
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