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Hydrophobic anions potently and uncompetitively antagonize GABA(A) receptor function in the absence of a conventional binding site
BACKGROUND AND PURPOSE: A ‘lock-and-key’ binding site typically accounts for the effect of receptor antagonists. However, sulphated neurosteroids are potent non-competitive antagonists of GABA(A) receptors without a clear structure–activity relationship. To gain new insights, we tested two structura...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Blackwell Publishing Ltd
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3188920/ https://ncbi.nlm.nih.gov/pubmed/21457224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01396.x |
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