Structurally diverse amphiphiles exhibit biphasic modulation of GABA(A) receptors: similarities and differences with neurosteroid actions

BACKGROUND AND PURPOSE: Some neurosteroids, notably 3α-hydroxysteroids, positively modulate GABA(A) receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulate GABA receptors. We examined whether there was s...

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Detalhes bibliográficos
Main Authors: Chisari, M, Shu, H-J, Taylor, A, Steinbach, JH, Zorumski, CF, Mennerick, S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860213/
https://ncbi.nlm.nih.gov/pubmed/20412070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00679.x
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