Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

BACKGROUND AND PURPOSE: Altered glutamatergic neurotransmission is linked to several neurological and psychiatric disorders. Metabotropic glutamate receptor 2 (mGlu(2)) plays an important role on the presynaptic control of glutamate release and negative allosteric modulators (NAMs) acting on mGlu(2/...

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Main Authors: Lundström, L, Bissantz, C, Beck, J, Wettstein, JG, Woltering, TJ, Wichmann, J, Gatti, S
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2011
Assuntos:
Themed Section: Drug Discovery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188907/
https://ncbi.nlm.nih.gov/pubmed/21470207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01409.x
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