Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads

We present a novel pipeline and methodology for simultaneously estimating isoform expression and allelic imbalance in diploid organisms using RNA-seq data. We achieve this by modeling the expression of haplotype-specific isoforms. If unknown, the two parental isoform sequences can be individually re...

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Hlavní autoři: Turro, Ernest, Su, Shu-Yi, Gonçalves, Ângela, Coin, Lachlan JM, Richardson, Sylvia, Lewin, Alex
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188795/
https://ncbi.nlm.nih.gov/pubmed/21310039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-2-r13
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