Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

We previously mapped a type 2 diabetes (T2D) locus on chromosome 16 (Chr 16) in an F2 intercross from the BTBR T (+) tf (BTBR) Lep(ob/ob) and C57BL/6 (B6) Lep(ob/ob) mouse strains. Introgression of BTBR Chr 16 into B6 mice resulted in a consomic mouse with reduced fasting plasma insulin and elevated...

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Main Authors: Bhatnagar, Sushant, Oler, Angie T., Rabaglia, Mary E., Stapleton, Donald S., Schueler, Kathryn L., Truchan, Nathan A., Worzella, Sara L., Stoehr, Jonathan P., Clee, Susanne M., Yandell, Brian S., Keller, Mark P., Thurmond, Debbie C., Attie, Alan D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188574/
https://ncbi.nlm.nih.gov/pubmed/21998599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002323
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