3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

[Image: see text] Histone–lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene transcription. Bromodomains bind acetylated lysines, acting as readers of the histone-acetylation code. Competitive inhibitors of this interaction have anti...

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Main Authors: Hewings, David S., Wang, Minghua, Philpott, Martin, Fedorov, Oleg, Uttarkar, Sagar, Filippakopoulos, Panagis, Picaud, Sarah, Vuppusetty, Chaitanya, Marsden, Brian, Knapp, Stefan, Conway, Stuart J., Heightman, Tom D.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2011
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188285/
https://ncbi.nlm.nih.gov/pubmed/21851057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200640v
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