Initiation of Polyene Macrolide Biosynthesis: Interplay between Polyketide Synthase Domains and Modules as Revealed via Domain Swapping, Mutagenesis, and Heterologous Complementation

Polyene macrolides are important antibiotics used to treat fungal infections in humans. In this work, acyltransferase (AT) domain swaps, mutagenesis, and cross-complementation with heterologous polyketide synthase domain (PKS) loading modules were performed in order to facilitate production of new a...

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Bibliografski detalji
Glavni autori: Heia, Sondre, Borgos, Sven E. F., Sletta, Håvard, Escudero, Leticia, Seco, Elena M., Malpartida, Francisco, Ellingsen, Trond E., Zotchev, Sergey B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Genetics and Molecular Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187094/
https://ncbi.nlm.nih.gov/pubmed/21821762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05781-11
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