Initiation of Polyene Macrolide Biosynthesis: Interplay between Polyketide Synthase Domains and Modules as Revealed via Domain Swapping, Mutagenesis, and Heterologous Complementation

Polyene macrolides are important antibiotics used to treat fungal infections in humans. In this work, acyltransferase (AT) domain swaps, mutagenesis, and cross-complementation with heterologous polyketide synthase domain (PKS) loading modules were performed in order to facilitate production of new a...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Heia, Sondre, Borgos, Sven E. F., Sletta, Håvard, Escudero, Leticia, Seco, Elena M., Malpartida, Francisco, Ellingsen, Trond E., Zotchev, Sergey B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
Предметы:
Genetics and Molecular Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187094/
https://ncbi.nlm.nih.gov/pubmed/21821762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05781-11
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы