Genome-Wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

While chromosomal translocations are common pathogenetic events in cancer, mechanisms that promote them are poorly understood. To elucidate translocation mechanisms in mammalian cells, we developed high throughput, genome-wide translocation sequencing (HTGTS). We employed HTGTS to identify tens of t...

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Detalhes bibliográficos
Main Authors: Chiarle, Roberto, Zhang, Yu, Frock, Richard L., Lewis, Susanna M., Molinie, Benoit, Ho, Yu-Jui, Myers, Darienne R., Choi, Vivian W., Compagno, Mara, Malkin, Daniel J., Neuberg, Donna, Monti, Stefano, Giallourakis, Cosmas C., Gostissa, Monica, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186939/
https://ncbi.nlm.nih.gov/pubmed/21962511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.07.049
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