Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm

Granzyme B (GZMB) is a proapoptotic serine protease that is released by cytotoxic lymphocytes. However, GZMB can also be produced by other cell types and is capable of cleaving extracellular matrix (ECM) proteins. GZMB contributes to abdominal aortic aneurysm (AAA) through an extracellular, perforin...

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Autors principals: Ang, L S, Boivin, W A, Williams, S J, Zhao, H, Abraham, T, Carmine-Simmen, K, McManus, B M, Bleackley, R C, Granville, D J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186906/
https://ncbi.nlm.nih.gov/pubmed/21900960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.88
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