Perforin-Independent Extracellular Granzyme B Activity Contributes to Abdominal Aortic Aneurysm

Granzyme B (GZMB) is a serine protease that is abundantly expressed in advanced human atherosclerotic lesions and may contribute to plaque instability. Perforin is a pore-forming protein that facilitates GZMB internalization and the induction of apoptosis. Recently a perforin-independent, extracellu...

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Detalhes bibliográficos
Main Authors: Chamberlain, Ciara M., Ang, Lisa S., Boivin, Wendy A., Cooper, Dawn M., Williams, Sarah J., Zhao, Hongyan, Hendel, Alon, Folkesson, Maggie, Swedenborg, Jesper, Allard, Michael F., McManus, Bruce M., Granville, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808106/
https://ncbi.nlm.nih.gov/pubmed/20035050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090700
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