Myc represses the p21((WAF1/CIP1)) promoter and interacts with Sp1/Sp3

The cyclin-dependent kinase inhibitor p21((WAF1/CIP1)) inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G(1) cell cycle arrest. Recent studies showed that Myc can...

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Bibliographic Details
Main Authors: Gartel, Andrei L., Ye, Xin, Goufman, Eugene, Shianov, Pavel, Hay, Nissim, Najmabadi, Feridoon, Tyner, Angela L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC31865/
https://ncbi.nlm.nih.gov/pubmed/11274368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081074898
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