Myc represses the p21((WAF1/CIP1)) promoter and interacts with Sp1/Sp3

The cyclin-dependent kinase inhibitor p21((WAF1/CIP1)) inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G(1) cell cycle arrest. Recent studies showed that Myc can...

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Bibliografiske detaljer
Main Authors: Gartel, Andrei L., Ye, Xin, Goufman, Eugene, Shianov, Pavel, Hay, Nissim, Najmabadi, Feridoon, Tyner, Angela L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC31865/
https://ncbi.nlm.nih.gov/pubmed/11274368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081074898
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