Myc represses the p21((WAF1/CIP1)) promoter and interacts with Sp1/Sp3
The cyclin-dependent kinase inhibitor p21((WAF1/CIP1)) inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G(1) cell cycle arrest. Recent studies showed that Myc can...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2001
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081074898 |
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