Myc represses the p21((WAF1/CIP1)) promoter and interacts with Sp1/Sp3
The cyclin-dependent kinase inhibitor p21((WAF1/CIP1)) inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G(1) cell cycle arrest. Recent studies showed that Myc can...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081074898 |
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