Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators

The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. We describe here two new progesterone receptor ligand binding domain x-ray str...

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Autores principales: Lusher, Scott J., Raaijmakers, Hans C. A., Vu-Pham, Diep, Dechering, Koen, Lam, Tsang Wai, Brown, Angus R., Hamilton, Niall M., Nimz, Olaf, Bosch, Rolien, McGuire, Ross, Oubrie, Arthur, de Vlieg, Jacob
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186393/
https://ncbi.nlm.nih.gov/pubmed/21849509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273029
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