Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer

The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controversial. In primary ER(+) (estrogen receptor–positive)/PR(+) human tumors, we report that PR reprograms estrogen signaling as a genomic agonist and a phenotypic antagonist. In isolati...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Singhal, Hari, Greene, Marianne E., Tarulli, Gerard, Zarnke, Allison L., Bourgo, Ryan J., Laine, Muriel, Chang, Ya-Fang, Ma, Shihong, Dembo, Anna G., Raj, Ganesh V., Hickey, Theresa E., Tilley, Wayne D., Greene, Geoffrey L.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928895/
https://ncbi.nlm.nih.gov/pubmed/27386569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501924
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