Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer

The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controversial. In primary ER(+) (estrogen receptor–positive)/PR(+) human tumors, we report that PR reprograms estrogen signaling as a genomic agonist and a phenotypic antagonist. In isolati...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Singhal, Hari, Greene, Marianne E., Tarulli, Gerard, Zarnke, Allison L., Bourgo, Ryan J., Laine, Muriel, Chang, Ya-Fang, Ma, Shihong, Dembo, Anna G., Raj, Ganesh V., Hickey, Theresa E., Tilley, Wayne D., Greene, Geoffrey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928895/
https://ncbi.nlm.nih.gov/pubmed/27386569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501924
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