Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer

The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controversial. In primary ER(+) (estrogen receptor–positive)/PR(+) human tumors, we report that PR reprograms estrogen signaling as a genomic agonist and a phenotypic antagonist. In isolati...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Singhal, Hari, Greene, Marianne E., Tarulli, Gerard, Zarnke, Allison L., Bourgo, Ryan J., Laine, Muriel, Chang, Ya-Fang, Ma, Shihong, Dembo, Anna G., Raj, Ganesh V., Hickey, Theresa E., Tilley, Wayne D., Greene, Geoffrey L.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928895/
https://ncbi.nlm.nih.gov/pubmed/27386569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501924
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