Progesterone receptor modulates estrogen receptor-α action in breast cancer

Progesterone receptor (PR) expression is employed as a biomarker of estrogen receptor-α (ERα) function and breast cancer prognosis. We now show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its behaviour. In the presence of agonist ligands, PR...

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Publicado en:Nature
Main Authors: Mohammed, Hisham, Russell, I. Alasdair, Stark, Rory, Rueda, Oscar M., Hickey, Theresa E., Tarulli, Gerard A., Serandour, Aurelien A. A., Birrell, Stephen N., Bruna, Alejandra, Saadi, Amel, Menon, Suraj, Hadfield, James, Pugh, Michelle, Raj, Ganesh V., Brown, Gordon D., D’Santos, Clive, Robinson, Jessica L. L., Silva, Grace, Launchbury, Rosalind, Perou, Charles M., Stingl, John, Caldas, Carlos, Tilley, Wayne D., Carroll, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650274/
https://ncbi.nlm.nih.gov/pubmed/26153859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14583
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