Progesterone receptor modulates estrogen receptor-α action in breast cancer

Progesterone receptor (PR) expression is employed as a biomarker of estrogen receptor-α (ERα) function and breast cancer prognosis. We now show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its behaviour. In the presence of agonist ligands, PR...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Mohammed, Hisham, Russell, I. Alasdair, Stark, Rory, Rueda, Oscar M., Hickey, Theresa E., Tarulli, Gerard A., Serandour, Aurelien A. A., Birrell, Stephen N., Bruna, Alejandra, Saadi, Amel, Menon, Suraj, Hadfield, James, Pugh, Michelle, Raj, Ganesh V., Brown, Gordon D., D’Santos, Clive, Robinson, Jessica L. L., Silva, Grace, Launchbury, Rosalind, Perou, Charles M., Stingl, John, Caldas, Carlos, Tilley, Wayne D., Carroll, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650274/
https://ncbi.nlm.nih.gov/pubmed/26153859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14583
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