Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood

Aspirin (acetylsalicylic acid) prophylaxis suppresses major adverse cardiovascular events, but its rapid turnover limits inhibition of platelet cyclooxygenase activity and thrombosis. Despite its importance, the identity of the enzyme(s) that hydrolyzes the acetyl residue of circulating aspirin, whi...

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Bibliografski detalji
Glavni autori: Zhou, Gang, Marathe, Gopal K., Willard, Belinda, McIntyre, Thomas M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Enzymology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186390/
https://ncbi.nlm.nih.gov/pubmed/21844189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.267161
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