Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells

Autotaxin (ATX) is a secreted lysophospholipase D that generates the bioactive lipid mediator lysophosphatidic acid (LPA). We and others have reported that ATX binds to integrins, but the function of ATX-integrin interactions is unknown. The recently reported crystal structure of ATX suggests a role...

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Bibliographic Details
Main Authors: Fulkerson, Zachary, Wu, Tao, Sunkara, Manjula, Kooi, Craig Vander, Morris, Andrew J., Smyth, Susan S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186383/
https://ncbi.nlm.nih.gov/pubmed/21832043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276725
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