Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration

Autotaxin (ATX) is a secreted lysophospholipase D (lysoPLD) that binds to integrin adhesion receptors. We dissected the roles of integrin binding and lysoPLD activity in stimulation of human breast cancer and mouse aortic vascular smooth muscle cell migration by ATX. We compared effects of wild-type...

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Autori principali: Wu, Tao, Kooi, Craig Vander, Shah, Pritom, Charnigo, Richard, Huang, Cai, Smyth, Susan S., Morris, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898650/
https://ncbi.nlm.nih.gov/pubmed/24277575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-232868
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