Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA). ATX-LPA signalling is involved in multiple biological and pathophysiological processes, including vasculogenesis, fibrosis, cholestatic pruritus and tumour progression. ATX has a tripartite active site, combining a hydrophilic...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Keune, Willem-Jan, Hausmann, Jens, Bolier, Ruth, Tolenaars, Dagmar, Kremer, Andreas, Heidebrecht, Tatjana, Joosten, Robbie P., Sunkara, Manjula, Morris, Andrew J., Matas-Rico, Elisa, Moolenaar, Wouter H., Oude Elferink, Ronald P., Perrakis, Anastassis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834639/
https://ncbi.nlm.nih.gov/pubmed/27075612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11248
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