Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency

Por Salgado-Polo, Fernando, Fish, Alex, Matsoukas, Minos-Timotheos, Heidebrecht, Tatjana, Keune, Willem-Jan, Perrakis, Anastassis
Publicado no J Biol Chem (2018)

The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress

Por Mans, Laurie A., Querol Cano, Laia, van Pelt, Jason, Giardoglou, Panagiota, Keune, Willem-Jan, Haramis, Anna-Pavlina G.
Publicado no Sci Rep (2017)

Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: a role for PIP4K2B in the regulation of E-cadherin expression

Por Keune, Willem-Jan, Sims, Andrew H., Jones, David R., Bultsma, Yvette, Lynch, James T., Jirström, Karin, Landberg, Goran, Divecha, Nullin
Publicado no Cancer Res (2013)

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

Por Keune, Willem-Jan, Hausmann, Jens, Bolier, Ruth, Tolenaars, Dagmar, Kremer, Andreas, Heidebrecht, Tatjana, Joosten, Robbie P., Sunkara, Manjula, Morris, Andrew J., Matas-Rico, Elisa, Moolenaar, Wouter H., Oude Elferink, Ronald P., Perrakis, Anastassis
Publicado no Nat Commun (2016)