An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737

The antiapoptotic BCL-2 proteins regulate lymphocyte survival and are over-expressed in lymphoid malignancies, including chronic lymphocytic leukemia. The small molecule inhibitor ABT-737 binds with high affinity to BCL-2, BCL-XL, and BCL-W but with low affinity to MCL-1, BFL-1, and BCL-B. The activ...

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Autors principals: Al-harbi, Sayer, Hill, Brian T., Mazumder, Suparna, Singh, Kamini, DeVecchio, Jennifer, Choudhary, Gaurav, Rybicki, Lisa A., Kalaycio, Matt, Maciejewski, Jaroslaw P., Houghton, Janet A., Almasan, Alexandru
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186334/
https://ncbi.nlm.nih.gov/pubmed/21772052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-340364
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