RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model

ABT-737 is a promising chemotherapeutic agent that promotes apoptosis by acting as a selective BH3 mimetic to neutralize Bcl-2–like family members. One shortcoming with its use is that Mcl-1, a member of the Bcl-2 family, is poorly inhibited by ABT-737 and thus is a major cause of resistance. We per...

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Bibliografische gegevens
Hoofdauteurs: Mills, John R., Malina, Abba, Lee, Teresa, Di Paola, Domenic, Larsson, Ola, Miething, Cornelius, Grosse, Frank, Tang, Hengli, Zannis-Hadjopoulos, Maria, Lowe, Scott W., Pelletier, Jerry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2013
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637015/
https://ncbi.nlm.nih.gov/pubmed/23440244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-434365
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