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Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16(INK4A)(−) human mammary epithelial cells

Failures to arrest growth in response to senescence or transforming growth factor β (TGF-β) are key derangements associated with carcinoma progression. We report that activation of telomerase activity may overcome both inhibitory pathways. Ectopic expression of the human telomerase catalytic subunit...

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Bibliografske podrobnosti
Main Authors: Stampfer, Martha R., Garbe, James, Levine, Gerri, Lichtsteiner, Serge, Vasserot, Alain P., Yaswen, Paul
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC31863/
https://ncbi.nlm.nih.gov/pubmed/11287649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071483998
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