Replacement of a Thiourea with an Amidine Group in a Monofunctional Platinum–acridine Antitumor Agent. Effect on DNA Interactions, DNA Adduct Recognition and Repair

A combination of biophysical, biochemical, and computational techniques was used to delineate mechanistic differences between the platinum–acridine hybrid agent [PtCl(en)(L)](NO(3))(2) (complex 1, en = ethane-1,2-diamine, L = 1-[2-(acridin-9-ylamino)ethyl]-1,3- dimethylthiourea) and a considerably m...

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Detalhes bibliográficos
Main Authors: Kostrhunova, Hana, Malina, Jaroslav, Pickard, Amanda J., Stepankova, Jana, Vojtiskova, Marie, Kašpárkova, Jana, Muchova, Tereza, Rohlfing, Matthew L., Bierbach, Ulrich, Brabec, Viktor
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185219/
https://ncbi.nlm.nih.gov/pubmed/21806015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200309x
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