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Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck
BACKGROUND: Due to the structural and biochemical similarities between the anti-tumor p53 and p73 proteins, we hypothesized that individuals who carry high risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) in patients...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3184342/ https://ncbi.nlm.nih.gov/pubmed/21717430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26222 |
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