Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β(1) Is Increased in Chronic Obstructive Pulmonary Disease

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by abnormal extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has been associated with abnormal ECM turnover in various chronic diseases. We determined WNT-pathway gene expression in pulmon...

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Detalhes bibliográficos
Main Authors: Baarsma, Hoeke A., Spanjer, Anita I. R., Haitsma, Gertruud, Engelbertink, Lilian H. J. M., Meurs, Herman, Jonker, Marnix R., Timens, Wim, Postma, Dirkje S., Kerstjens, Huib A. M., Gosens, Reinoud
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184127/
https://ncbi.nlm.nih.gov/pubmed/21980461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025450
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