Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology

BACKGROUND: Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase that regulates multiple signalling proteins and transcription factors involved in a myriad of cellular processes. The kinase acts as a negative regulator in β-catenin signalling and is critically involved in the smad pa...

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Detalhes bibliográficos
Main Authors: Baarsma, Hoeke A, Bos, Sophie, Meurs, Herman, Visser, Kim H, Smit, Marieke, Schols, Annemie MWJ, Langen, Ramon C, Kerstjens, Huib AM, Gosens, Reinoud
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015129/
https://ncbi.nlm.nih.gov/pubmed/24152196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-113
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