Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B

BACKGROUND: Development of the hepatitis B virus (HBV) rtA181T/sW172* mutant could occur during prolonged lamivudine (LAM) therapy, conferring cross resistance to adefovir. Recent studies demonstrated an increased oncogenic potential of this mutant in NIH3T3 cells. In this study, we aimed to investi...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yeh, Chau-Ting, Chen, Tiffany, Hsu, Chao-Wei, Chen, Yi-Cheng, Lai, Ming-Wei, Liang, Kung-Hao, Chen, Tse-Ching
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184121/
https://ncbi.nlm.nih.gov/pubmed/21933446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-398
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