Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B

BACKGROUND: Development of the hepatitis B virus (HBV) rtA181T/sW172* mutant could occur during prolonged lamivudine (LAM) therapy, conferring cross resistance to adefovir. Recent studies demonstrated an increased oncogenic potential of this mutant in NIH3T3 cells. In this study, we aimed to investi...

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Hlavní autoři: Yeh, Chau-Ting, Chen, Tiffany, Hsu, Chao-Wei, Chen, Yi-Cheng, Lai, Ming-Wei, Liang, Kung-Hao, Chen, Tse-Ching
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184121/
https://ncbi.nlm.nih.gov/pubmed/21933446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-398
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