A role for intermolecular disulfide bonds in prion diseases?

The key event in prion diseases seems to be the conversion of the prion protein PrP from its normal cellular isoform (PrP(C)) to an aberrant “scrapie” isoform (PrP(Sc)). Earlier studies have detected no covalent modification in the scrapie isoform and have concluded that the PrP(C) → PrP(Sc) convers...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Welker, Ervin, Wedemeyer, William J., Scheraga, Harold A.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2001
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31835/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274354/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071066598
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