A role for intermolecular disulfide bonds in prion diseases?
The key event in prion diseases seems to be the conversion of the prion protein PrP from its normal cellular isoform (PrP(C)) to an aberrant “scrapie” isoform (PrP(Sc)). Earlier studies have detected no covalent modification in the scrapie isoform and have concluded that the PrP(C) → PrP(Sc) convers...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2001
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31835/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274354/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071066598 |
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