Inhibition of Glycogen Synthase Kinase-3β Counteracts Ligand-Independent Activity of the Androgen Receptor in Castration Resistant Prostate Cancer

In order to generate genomic signals, the androgen receptor (AR) has to be transported into the nucleus upon androgenic stimuli. However, there is evidence from in vitro experiments that in castration-resistant prostate cancer (CRPC) cells the AR is able to translocate into the nucleus in a ligand-i...

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Main Authors: Schütz, Stefanie V., Schrader, Andres J., Zengerling, Friedemann, Genze, Felicitas, Cronauer, Marcus V., Schrader, Mark
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183056/
https://ncbi.nlm.nih.gov/pubmed/21980429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025341
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