DNA methylation of SPARC and chronic low back pain

BACKGROUND: The extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine) has been linked to degeneration of the intervertebral discs and chronic low back pain (LBP). In humans, SPARC protein expression is decreased as a function of age and disc degeneration. In mice, inactivat...

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Détails bibliographiques
Auteurs principaux: Tajerian, Maral, Alvarado, Sebastian, Millecamps, Magali, Dashwood, Thomas, Anderson, Kathleen M, Haglund, Lisbet, Ouellet, Jean, Szyf, Moshe, Stone, Laura S
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182907/
https://ncbi.nlm.nih.gov/pubmed/21867537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-65
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