DNA methylation of SPARC and chronic low back pain

BACKGROUND: The extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine) has been linked to degeneration of the intervertebral discs and chronic low back pain (LBP). In humans, SPARC protein expression is decreased as a function of age and disc degeneration. In mice, inactivat...

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Hlavní autoři: Tajerian, Maral, Alvarado, Sebastian, Millecamps, Magali, Dashwood, Thomas, Anderson, Kathleen M, Haglund, Lisbet, Ouellet, Jean, Szyf, Moshe, Stone, Laura S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182907/
https://ncbi.nlm.nih.gov/pubmed/21867537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-65
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