Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques

In the course of developing a low-density lipoprotein receptor (LDLR) gene therapy treatment for homozygous familial hypercholesterolemia (HoFH), we planned to examine the efficacy in a nonhuman primate model, the rhesus macaque heterozygous for an LDL receptor mutation fed a high-fat diet. Unexpect...

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Détails bibliographiques
Auteurs principaux: Kassim, Sadik H., Vandenberghe, Luk H., Hovhannisyan, Ruben, Wilson, James M., Rader, Daniel J.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2011
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180732/
https://ncbi.nlm.nih.gov/pubmed/21628398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00006.2011
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