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Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques
In the course of developing a low-density lipoprotein receptor (LDLR) gene therapy treatment for homozygous familial hypercholesterolemia (HoFH), we planned to examine the efficacy in a nonhuman primate model, the rhesus macaque heterozygous for an LDL receptor mutation fed a high-fat diet. Unexpect...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3180732/ https://ncbi.nlm.nih.gov/pubmed/21628398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00006.2011 |
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