Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin

PURPOSE: Luteinizing hormone receptor (LHR) is found in abundance on human ovarian, breast, endometrial and prostate carcinomas but at only low levels on non-gonadal tissues. To selectively kill LHR-expressing tumors, granzyme B (GrB) was linked to a protein in which both chains of human chorionic g...

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Autors principals: Kanatani, Isao, Lin, Xinjian, Yuan, Xiaoqin, Manorek, Gerald, Shang, Xiying, Cheung, Lawrence H., Rosenblum, Michael G., Howell, Stephen B.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180622/
https://ncbi.nlm.nih.gov/pubmed/21327682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1573-4
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