Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

BACKGROUND: Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remains a particular challenge. Claudins 3 and 4 are tight junction proteins that ar...

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Bibliografiska uppgifter
Huvudupphovsmän: Yuan, Xiaoqin, Lin, Xinjian, Manorek, Gerald, Howell, Stephen B
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042419/
https://ncbi.nlm.nih.gov/pubmed/21303546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-61
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