Regiospecific inhibition of DNA duplication by antisense phosphate-methylated oligodeoxynucleotides.

A new synthesis route for long phosphate-methylated oligodeoxynucleotides is described, which were used as antisense inhibitors of the DNA replication. Phosphate-methylated oligomers hybridize more strongly with natural DNA than their natural analogues, due to the absence of electrostatic interstran...

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Bibliografiska uppgifter
Huvudupphovsmän: Moody, H M, van Genderen, M H, Koole, L H, Kocken, H J, Meijer, E M, Buck, H M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1989
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC318031/
https://ncbi.nlm.nih.gov/pubmed/2748337
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